Potential value of circulating corin levels in acute and chronic myocardial infarction

Dong Wang, Guy L. Reed


In the heart, corin is a membrane-anchored, serine protease that cleaves and activates pro-ANP and pro-BNP, thereby modulating salt-water balance, vasodilatation and cardiac function (1). Cardiac corin can also be released from cardiomyocyte membranes and enter the circulation as a soluble form, where it can readily be measured in the blood.