Uromodulin, a novel biomarker for cardiovascular risk assessment?

Uromodulin (Tamm-Horsfall protein) is a renal specific glycoprotein produced by the epithelial cells of the thick ascending limb of the loop of Henle. Several important roles have been identified for uromodulin including ion transportation, water maintenance, electrolyte balance and innate immunity of the urinary tract (1,2).