Discrepant impacts of age and gender factors on serum pepsinogens and gastrin-17 levels

Jian-Fang Lou, Xian Chen, Jie-Xin Zhang, Yan Zhang


Background: To explore the effect of age and gender on serum pepsinogen I (PGI), pepsinogen II (PGII), and gastrin-17 (G-17) levels.
Methods: We recruited 2,732 people who underwent physical examination in our hospital and detected their serum PGI, PGII, and G-17 levels by enzyme-linked immunosorbent assay (ELISA). We applied one-way ANOVA, Student’s t-test, and Spearman correlation, one way analysis of variance, Tukey test, and non-parametric 95% percentile method for statistical analysis.
Results: In both males and females, PGI, PGII and G-17 were positively correlated with age. Males had significantly higher PGI and PGII than females, while G-17 was not affected by gender. Besides, we established the gender and age specific reference intervals for PGs and G-17.
Conclusions: Both age and gender should be taken into consideration when interpreting serum PGI, PGII, and G-17 results.