Is glycemic variability associated with a risk of Alzheimer’s disease in older adults with diabetes mellitus?

Soledad Ballesteros, María Teresa Redondo


Alzheimer’s disease (AD) is the most common form of senile dementia, accounting for more than half of all cases of dementia (1). This neurodegenerative disorder is the most common cause of death among older adults. Around 10% of elders over 70 years of age in the USA suffer from this type of dementia (2). Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that occurs when the body cannot effectively use the insulin it produces and when the pancreas does not produce enough insulin. The global prevalence of diabetes reached 8.5% of the adult population in 2016. The prevalence of T2DM in older adults is a global health issue, causing 1.5 million deaths in 2012 (3).