Article Abstract

Can urinary exosomal micro-RNA detection become a diagnostic and prognostic gold standard for patients with lupus nephritis and diabetic nephropathy?

Authors: Chang-Youh Tsai, Ming-Chi Lu, Chia-Li Yu

Abstract

In 1993, Lee et al. (1) observed that lin-4 gene could control the embryonic development of C. elegans, but failed to encode a protein molecule. Besides, the gene transcribes a pair of microRNAs (miRNAs). The short RNA is approximately 22 nucleotides (nt) in length whereas the long one is 61 nt that was predicted to fold a stem loop with anti-sense complementary to 3'-untranslated region (UTR) of lin-14 messenger RNA (mRNA) (2).

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