Article Abstract

Advances in pediatric reference intervals: from discrete to continuous

Authors: Victoria Higgins, Khosrow Adeli

Abstract

The clinical utility of laboratory tests largely relies on availability of normative ranges (i.e., reference intervals) to enable objective interpretation and clinical decision making. Establishing accurate reference intervals is often beyond the capabilities of individual laboratories, requiring recruitment of a sufficiently large, healthy reference population, which becomes even more challenging in the pediatric population.