The state-of-the-art of “high-sensitivity” immunoassay for measuring cardiac troponin I and T

The international guidelines “on the Redefinition of AMI”, published in 2000 by the Joint European Society of Cardiology/American College of Cardiology (ESC/ACC) Committee, for the first time recommended that an increase of cardiac troponin I (cTnI) or T (cTnT) values over the 99^th percentile upper reference limit (99^th URL) should be considered as clinically significant, and they also specifically indicated that this thresholds value should be measured with an imprecision ≤10 coefficient of variation (CV%) (1).