Article Abstract

The state-of-the-art of “high-sensitivity” immunoassay for measuring cardiac troponin I and T

Authors: Aldo Clerico, Giuseppe Lippi


The international guidelines “on the Redefinition of AMI”, published in 2000 by the Joint European Society of Cardiology/American College of Cardiology (ESC/ACC) Committee, for the first time recommended that an increase of cardiac troponin I (cTnI) or T (cTnT) values over the 99th percentile upper reference limit (99th URL) should be considered as clinically significant, and they also specifically indicated that this thresholds value should be measured with an imprecision ≤10 coefficient of variation (CV%) (1).