Article Abstract

Biomarkers in Barrett’s oesophagus

Authors: Thomas Riley, Huw Purssell, Yeng Ang

Abstract

Barrett’s oesophagus (BO) is the most important risk factor for oesophageal adenocarcinoma (OAC) and its incidence, as well as the cancer it precedes, is increasing. Evidence suggests that current methods of screening and surveillance are inadequate and therefore more clinically and cost effective techniques have been sought. With a better understanding of oesophageal adenocarcinoma and cancer in general, several genetic biomarkers have been identified which could be used to better diagnose and risk stratify patients. In this article we review current evidence for biomarkers in BO as well as identifying some of the problems yet to be overcome to allow their transition into clinical practice.