Bilirubin and migraine: critical review of the literature

We read with interest the recent article published by Peng et al. (1), who provided a comprehensive overview on the multiple clinical usefulness of measuring total bilirubin in serum or plasma. Among the various potential applications, the authors highlighted that total bilirubin was found to be lower in patients with migraine than in those without, a conclusion that was supported by a cross-sectional study published by the lead author of the review article (2).