DNA damage assessment for precision medicine: an emerging diagnostic option

Dirk Roggenbuck


DNA damage analysis is an evolving diagnostic field, particularly for precision medicine, that opens new avenues for the use of potential biomarkers such as the phosphorylated histone 2Ax (γH2AX), 8-hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) (1-3). In fact, innovative diagnostic techniques have moved into the limelight that make it possible to analyze a plethora of new potential biomarkers, which requires the awareness of experts in laboratory medicine and beyond.